This is consistent with the known role of GLP-1R [49,60] and GIPR [37,38] agonism to reduce food intake, primarily but not exclusively via CNS mediated signaling events, and GcgR agonism to induce energy expenditure [54] through mechanisms that are not fully described
These effects are temporary and usually fade with continued use
Enhanced Insulin Secretion: GLP-1 receptor activation leads to increased insulin secretion from pancreatic beta-cells in a glucose-dependent manner, meaning it promotes insulin release when glucose levels are high, reducing the risk of hypoglycemia
Concentrate on the patients visible results, comfort, and safety
Rex DK, Ahnen DJ, Baron JA, Batts KP, Burke CA, Burt RW et al (2012) Serrated lesions of the colorectum: review and recommendations from an expert panel